ABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.
Subject(s)
Aged , Humans , Male , Adenocarcinoma, Mucinous , Eyelids , Groin , Head , Mucins , Paget Disease, Extramammary , Sweat GlandsABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.
Subject(s)
Humans , Male , Middle Aged , Adenocarcinoma, Mucinous , Cicatrix , Diagnosis , Eccrine Glands , Eyelids , Head , Mucins , Neck , Postoperative Complications , Recurrence , Skin , Skin NeoplasmsABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. The lesion was considered to be benign, and the initial treatment was simple excision with a 3-mm margin. However, histologic examination revealed the diagnosis of PCMC, and the patient underwent re-excision of the tumor site with an additional 3-mm margin from the initial scar. Histologic study of this second margin was free of any malignant cells. The patient experienced no postoperative complication or recurrence after 2 years. In our case, the skin lesion had benign morphologic findings and was strongly suspected to be a benign mass. Physicians should be aware of this tumor and be able to differentiate it from benign cystic or solid eyelid lesions.
Subject(s)
Humans , Male , Middle Aged , Adenocarcinoma, Mucinous , Cicatrix , Diagnosis , Eccrine Glands , Eyelids , Head , Mucins , Neck , Postoperative Complications , Recurrence , Skin , Skin NeoplasmsABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor believed to originate from the eccrine gland. It is important to exclude other possible origins of the mucinous carcinoma, such as the breast, lung, gastrointestinal tract, kidney, prostate, and ovary, because PCMC generally shows a better prognosis. Some histopathological clues are helpful to distinguish PCMC from metastatic mucinous carcinoma, but the final diagnosis should be made after a thorough systemic evaluation. We report a case of PCMC after a comprehensive evaluation to exclude metastatic mucinous carcinoma.
Subject(s)
Female , Adenocarcinoma, Mucinous , Breast , Diagnosis , Eccrine Glands , Gastrointestinal Tract , Kidney , Lung , Mucins , Ovary , Prognosis , Prostate , ScalpABSTRACT
Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor believed to originate from the eccrine gland. It is important to exclude other possible origins of the mucinous carcinoma, such as the breast, lung, gastrointestinal tract, kidney, prostate, and ovary, because PCMC generally shows a better prognosis. Some histopathological clues are helpful to distinguish PCMC from metastatic mucinous carcinoma, but the final diagnosis should be made after a thorough systemic evaluation. We report a case of PCMC after a comprehensive evaluation to exclude metastatic mucinous carcinoma.
Subject(s)
Female , Adenocarcinoma, Mucinous , Breast , Diagnosis , Eccrine Glands , Gastrointestinal Tract , Kidney , Lung , Mucins , Ovary , Prognosis , Prostate , ScalpABSTRACT
Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy shows dermal epithelial cell islands embedded in mucin pools separated by fibrous septae. It is difficult to differentiate this tumor histologically from metastatic adenocarcinoma. Recurrence after excision is common but metastases are rare. We report a primary cutaneous mucinous carcinoma with neuroendocrine differentiation on the right cheek of a 63-year-old man.